Early bets for NFL Week 10: Two games we're jumping on now

Early bets for Week 10: 49ers triumph in Dallas, low scoring in Texans-Browns?

• ESPN

Nov 9, 2026, 11:00 AM ET

Week 9 of the NFL season wraps up with Monday night's Bills-Vikings matchup (8:15 p.m. ET on ESPN), but we're already looking ahead to Week 10. Which games grabbed our analysts' attention?

The San Francisco 49ers rebounded from their first loss of the season with a win over the Las Vegas Raiders in Week 9 and will look to keep the momentum going Sunday on the road against the Dallas Cowboys, who narrowly defeated the Indianapolis Colts.

The Houston Texans kept the Los Angeles Chargers winless with an easy victory this past Sunday and in Week 10 will visit the Cleveland Browns, whose failed 2-point conversion near the end of overtime left them with their second straight loss.

Who do we like? Matt Bowen and Pamela Maldonado break down the games and share the bets they're backing before potential odds shifts later in the week.

Note: Odds by DraftKings and subject to change.

Check out the latest Super Bowl odds and major NFL awards futures.

San Francisco 49ers -3.5 at Dallas Cowboys

Bowen: Kyle Shanahan will have answers for both the run and pass game Sunday in Dallas. Schemed throws for Brock Purdy that create open coverage voids off play-action, plus a multiple run game with Christian McCaffrey and Kaelon Black to attack a Cowboys defense allowing 5.0 YPC (third most). I like the 49ers to cover on the road.

Last week: Bengals -3 vs. Falcons (Result: Bengals 34-Falcons 17)

Houston Texans at Cleveland Browns UNDER 39.5

Maldonado: Neither offense runs the ball well, which puts this game on the quarterbacks. Cleveland has allowed 38 sacks. Houston's pass rush kills drives. Shedeur Sanders threw for nearly 300 yards in Week 9, but the Browns scored only 16 points in regulation. Cleveland's secondary can challenge Houston's biggest offensive strength, C.J. Stroud. I see plenty of sacks and Houston potentially controlling this game, limiting Sanders and the Browns to keep this under the total.

Last week: Cowboys-Colts OVER 52 (Result: Cowboys 27, Colts 23)