WATCH: Democrat Annie Andrews' full victory speech after flipping South Carolina Senate seat

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Democrat Annie Andrews won election Tuesday to the U.S. Senate representing South Carolina, defeating Republican incumbent Darline Graham.

Watch Andrews speak in the video player above.

Andrews' victory in a state President Donald Trump won three times by double digits is a stark defeat for the Republican Party. A pediatrician, Andrews had previously run unsuccessfully for the U.S. House.

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Graham was appointed to the seat of her brother, the late Sen. Lindsey Graham, who died unexpectedly in July. She later won a contentious special primary for the Republican nomination with Trump's backing.

The Associated Press declared Andrews the winner at 10:39 p.m. EST.

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